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60 Minutes story on using polio virus to treat glioblastomas

The Spin Meister

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Nov 27, 2012
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An altered state
Fascinating new approaches to treating cancer include using viruses to stimulate the immune system into attacking cancer. Duke U is using a genetically modified polio virus to treat glioblastomas, a brain tumor that is almost 100% deadly in six months or less. In Phase I tests they have successfully treated several patients, including a couple that have lived three years and show no signs of cancer. The FDA is going to consider granting it breakthrough status, fast tracking it for wider use.

There are several other viral-based treatments under research/testing. The next five years could see huge breakthroughs in cancer treatments. Yeah, we have heard that many times before. Hoping this time is it.
 
I caught that story last night after the BB game..fascinating indeed **

vb
 
Wait, isn't everybody always saying genetically modified is bad? *

*
 
There was an HBO Vice story on this a few weeks ago

About using measles and even HIV to cure cancer and it is working in folks (which your link alludes to). Many are calling it the next breakthrough in cancer treatment. FDA has it all on the fast track. Lots of excitement.
 
Yeah, I'm poking fun.

People go crazy against GMO foods, calling them Frankenfoods, acting like they're evil, yadda, yadda. Of course, just crossbreeding plants creates a GMO but nobody thinks of it like that.

Whatever works and is safe, go for it. I have nothing per se against GM anything. I'm just poking fun at the fundamentalists.
 
Re: Yeah, I'm poking fun.

There are serious concerns about using GM polio. It took seven yrs of testing just to get approval to try it. GM is serious science that could be tremendously beneficial. But it could have a catastrophic affect is something goes wrong. And with more and more labs doing it, and the technologies cheaper and easier to use, the danger is definitely real.
 
Re: Yeah, I'm poking fun.

I see what you are saying now. The biggest problem with GMO's isn't so much the effects on the human body, which in a vacuum, is none, but in the world may be great.

The problem to me is that in many cases, what they are modifying is so that the plant won't die when you pour more chemicals on them. Those chemicals go into the ground and eventually into the ocean. The plants themselves still retain some of that when you get it. The fish you eat have it in it. And all kinds of environmental havoc occurs.

For instance, the monarch butterfly is starting to go extinct. Why? Because there is no more milkweed to eat on its migration. Why? Because now farmers can kill it without killing their crops. So a species that used to have hundreds of millions of insects, now has a fraction of that.

This kind of thing occurs with other species and the decline of those species has an unknown effect to the environment as a whole.

That is why I have a problem with GMOs. On a purely molecular level, sure, your body doesn't process them any different than nonGMO's but their impact can be much greater on the world. Further, you know what chemical they are pouring on the crops to kill the milkweed that starves the butterflys? Round Up. Which recently has been reported that it "probably" causes cancer.
 
Re: Yeah, I'm poking fun.

First of all, this might seem like semantics but I think it's a subtle thing that affects how people end up seeing things. You wrote:

"The problem to me is that in many cases, what they are modifying is so that the plant won't die when you pour more chemicals on them."

That implies that plants are one thing and then there are "chemical" (which people see as a bad thing) as something different. But note that the plant IS chemicals. For that matter, literally everything is chemicals. A carcinogen is something that in a high enough dose causes cancer in rats and thus (we assume) humans. Most if not all plants contain carcinogens and that's because they have to evolve defenses against pests in order to survive. If something is synthetic and created by humans then it has to be tested but something naturally occurring in plants does not. Plants aren't trying to be healthy for humans, rather they're just trying to survive. If a plant evolves a chemical defense against a pest and that chemical causes cancer in humans 25 years down the road, the plant doesn't care. People have this notion of plants as pristine, pure things, but they're not.

So that's nature on it's own. And then we humans can involve ourselves in that in order to make the plants grow better or whatever in an effort to get more food for ourselves. And whatever we do, whatever technology or chemicals we develop, etc, can be good or not good or whatever. Roundup was recently put into Category 2A of the IARC list but that doesn't mean it's giving people that eat food cancer. I honestly don't know the details but I suspect the danger is to the people spraying it all day if they don't have some kind of protection. I do know that other things on that same list (2A) that "probably cause cancer" are working night shifts and being a barber or a hairdresser.

Don't get me wrong, we should investigate everything and be careful about everything but I think there can be anti-GMO hysteria too and Roundup is often a target for that.
 
That was a great 60 minutes report which I caught simply because it followed the basketball game. Give a lot of credit to that 20 year old patient number 1. When the tumor looked like it was getting worse after the polio injection the doctors wanted to go back to conventional radiation/ chemo treatment. She said no, give it time. Brave young lady as it was only the body's immune system kicking in and causing serious inflammation, making it look worse on x rays.
 
Yes, that's symantics. Most people can tell the difference between...

...putting water (a chemical) around plants, vs putting round up (a chemical) around plants.
 
^^^^^I recommend watching this, too........................

You know, we think of ourselves as "advanced". I must say, the limited knowledge I have, viruses are quite fascinating.

Just "big picture", having a virus attack a cancer cell makes a lot of sense. I think this research holds a great deal of promise. Watching the show and seeing those kids be cancer free really brought tears to my eyes and a big smile to my face for all the researchers.
 
...I also watched the program...

...as I recall 11 of first 17 have not survived the treatment...

...they still don't have everything figured out...

...but it's a good start...
 
many years ago there was a breakthrough called "Interferons"

which was about the notion that people rarely get sick from something, when they are already sick with something else. they found this interferon and it was all the rage. Not a lot came out of it but this sounds similar in the sense that it is interferon-like theory, but instead of being general, its more targeted (specific disease targeting specific cancers). Is that right?
 
True about the 11 who died but that was when they were upping the dosage in the trials to 3 times what patient #1 received. They are now down to half of the original dose. Simply what they do in "trials". All of the patients had exhausted every known approach including surgery, to no avail, before taking part in the trials.
 
Re: ^^^^^I recommend watching this, too........................

having a virus attack a cancer cell makes a lot of sense.


Thats not quite accurate, as I understand it. The polio virus does not attack and kill the cancer cells. It causes changes in the cancer cells that allow the body's immune system to attack it. IIRC, the polio virus replicates in the cancer cells and parts of it get incorporated into the cells, probably in the cell wall. This is most likely receptor sites that the body recognizes as foreign and then attacks.

How the virus stays in just the tumor and not into other normal cells, I don't know. Cancer cells reproduce at a rapid rate maybe they incorporate them quicker. By the time that normal cells would replicate the bad receptor sites, the immune system would stop it ASAP, thus limiting the damage.......I think.

Other researchers are trying different viruses as they may be better at being incorporated into different cancer cells. Having a wider range of weapons would be very helpful.
 
I head of one at PSU that used

the common cold virus - in fact this was some of the initial work being done in the field - it was several years ago that I read the article.
 
It will get approved

And if you don't think Big P isn't way ahead of this with with a profit model lined up, then I've got a new tin foil hat to sell you :)
 
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