In my opinion, the biggest upset of the weekend was #17 Wanzek over #2 Massa; that was definitely not expected.
Other notable upsets:
#7 Lee over #1 Tomasello
#3 Hall (285) of ASU losing twice this weekend
#137 Colbray (ISU) over #13 Jake Smith
#120 Aaron Naples (Ohio) over #19 Kyle Conel
125 - #7 Spencer Lee (Iowa) beat #1 Nathan Tomasello (Ohio State) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/49146/lee-spencer/profile
125 - #10 Drew Mattin (Michigan) beat #4 Ethan Lizak (Minnesota) by TB-1 4 - 2 http://www.wrestlestat.com/wrestler/49180/mattin-drew/profile
125 - #14 Ryan Millhof (Arizona State) beat #5 Ronnie Bresser (Oregon State) by DEC 9 - 4 http://www.wrestlestat.com/wrestler/20815/millhof-ryan/profile
133 - #21 Korbin Myers (Edinboro) beat #10 Dennis Gustafson (Virginia Tech) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/39637/myers-korbin/profile
133 - #156 Jason Renteria (Nebraska) beat #14 Scott DelVecchio (Rutgers) by DEC 14 - 11 http://www.wrestlestat.com/wrestler/49208/renteria-jason/profile
141 - #5 Bryce Meredith (Wyoming) beat #1 Seth Gross (South Dakota State) by DEC 4 - 2 http://www.wrestlestat.com/wrestler/20135/meredith-bryce/profile
141 - #44 Cole Weaver (Indiana) beat #18 Javier Gasca (Michigan State) by DEC 2 - 1 http://www.wrestlestat.com/wrestler/20529/weaver-cole/profile
141 - #32 Eli Stickley (Wisconsin) beat #18 Javier Gasca (Michigan State) by DEC 6 - 2 http://www.wrestlestat.com/wrestler/39697/stickley-eli/profile
149 - #12 Grant Leeth (Missouri) beat #4 Justin Oliver (Central Michigan) by DEC 3 - 1 http://www.wrestlestat.com/wrestler/19866/leeth-grant/profile
157 - #17 Andrew Crone (Wisconsin) beat #7 Alec Pantaleo (Michigan) by DEC 3 - 0 http://www.wrestlestat.com/wrestler/13197/crone-andrew/profile
157 - #34 Andrew Shomers (Edinboro) beat #13 Bryant Clagon (Rider) by DEC 4 - 3 http://www.wrestlestat.com/wrestler/39642/shomers-andrew/profile
165 - #17 Nick Wanzek (Minnesota) beat #2 Logan Massa (Michigan) by DEC 14 - 8 http://www.wrestlestat.com/wrestler/11511/wanzek-nick/profile
174 - #29 Matt Finesilver (Duke) beat #18 Daniel Bullard (North Carolina State) by DEC 8 - 5 http://www.wrestlestat.com/wrestler/47770/finesilver-matt/profile
174 - #28 Dean Sherry (Rider) beat #19 Ty Schoffstall (Edinboro) by MD 21 - 12 http://www.wrestlestat.com/wrestler/40019/sherry-dean/profile
184 - #55 Canten Marriott (Missouri) beat #11 Jordan Ellingwood (Central Michigan) by MD 9 - 1 http://www.wrestlestat.com/wrestler/44723/marriott-canten/profile
184 - #104 Paul Dunn (Lehigh) beat #16 Noah Stewart (Army) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/40247/dunn-paul/profile
184 - #39 Alex DeCiantis (Drexel) beat #16 Noah Stewart (Army) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/12387/deciantis-alex/profile
197 - #30 Hunter Ritter (Wisconsin) beat #10 Kevin Beazley (Michigan) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/39783/ritter-hunter/profile
197 - #137 Samuel Colbray (Iowa State) beat #13 Jake A Smith (West Virginia) by SV-1 6 - 5 http://www.wrestlestat.com/wrestler/44873/colbray-samuel/profile
197 - #120 Aaron Naples (Ohio) beat #19 Kyle Conel (Kent State) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/51351/naples-aaron/profile
285 - #10 Amarveer Dhesi (Oregon State) beat #3 Tanner Hall (Arizona State) by DEC 9 - 5 http://www.wrestlestat.com/wrestler/14223/dhesi-amarveer/profile
285 - #9 Nathan Butler (Stanford) beat #3 Tanner Hall (Arizona State) by TB-2 3 - 2 http://www.wrestlestat.com/wrestler/14443/butler-nathan/profile
Other notable upsets:
#7 Lee over #1 Tomasello
#3 Hall (285) of ASU losing twice this weekend
#137 Colbray (ISU) over #13 Jake Smith
#120 Aaron Naples (Ohio) over #19 Kyle Conel
125 - #7 Spencer Lee (Iowa) beat #1 Nathan Tomasello (Ohio State) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/49146/lee-spencer/profile
125 - #10 Drew Mattin (Michigan) beat #4 Ethan Lizak (Minnesota) by TB-1 4 - 2 http://www.wrestlestat.com/wrestler/49180/mattin-drew/profile
125 - #14 Ryan Millhof (Arizona State) beat #5 Ronnie Bresser (Oregon State) by DEC 9 - 4 http://www.wrestlestat.com/wrestler/20815/millhof-ryan/profile
133 - #21 Korbin Myers (Edinboro) beat #10 Dennis Gustafson (Virginia Tech) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/39637/myers-korbin/profile
133 - #156 Jason Renteria (Nebraska) beat #14 Scott DelVecchio (Rutgers) by DEC 14 - 11 http://www.wrestlestat.com/wrestler/49208/renteria-jason/profile
141 - #5 Bryce Meredith (Wyoming) beat #1 Seth Gross (South Dakota State) by DEC 4 - 2 http://www.wrestlestat.com/wrestler/20135/meredith-bryce/profile
141 - #44 Cole Weaver (Indiana) beat #18 Javier Gasca (Michigan State) by DEC 2 - 1 http://www.wrestlestat.com/wrestler/20529/weaver-cole/profile
141 - #32 Eli Stickley (Wisconsin) beat #18 Javier Gasca (Michigan State) by DEC 6 - 2 http://www.wrestlestat.com/wrestler/39697/stickley-eli/profile
149 - #12 Grant Leeth (Missouri) beat #4 Justin Oliver (Central Michigan) by DEC 3 - 1 http://www.wrestlestat.com/wrestler/19866/leeth-grant/profile
157 - #17 Andrew Crone (Wisconsin) beat #7 Alec Pantaleo (Michigan) by DEC 3 - 0 http://www.wrestlestat.com/wrestler/13197/crone-andrew/profile
157 - #34 Andrew Shomers (Edinboro) beat #13 Bryant Clagon (Rider) by DEC 4 - 3 http://www.wrestlestat.com/wrestler/39642/shomers-andrew/profile
165 - #17 Nick Wanzek (Minnesota) beat #2 Logan Massa (Michigan) by DEC 14 - 8 http://www.wrestlestat.com/wrestler/11511/wanzek-nick/profile
174 - #29 Matt Finesilver (Duke) beat #18 Daniel Bullard (North Carolina State) by DEC 8 - 5 http://www.wrestlestat.com/wrestler/47770/finesilver-matt/profile
174 - #28 Dean Sherry (Rider) beat #19 Ty Schoffstall (Edinboro) by MD 21 - 12 http://www.wrestlestat.com/wrestler/40019/sherry-dean/profile
184 - #55 Canten Marriott (Missouri) beat #11 Jordan Ellingwood (Central Michigan) by MD 9 - 1 http://www.wrestlestat.com/wrestler/44723/marriott-canten/profile
184 - #104 Paul Dunn (Lehigh) beat #16 Noah Stewart (Army) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/40247/dunn-paul/profile
184 - #39 Alex DeCiantis (Drexel) beat #16 Noah Stewart (Army) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/12387/deciantis-alex/profile
197 - #30 Hunter Ritter (Wisconsin) beat #10 Kevin Beazley (Michigan) by DEC 3 - 2 http://www.wrestlestat.com/wrestler/39783/ritter-hunter/profile
197 - #137 Samuel Colbray (Iowa State) beat #13 Jake A Smith (West Virginia) by SV-1 6 - 5 http://www.wrestlestat.com/wrestler/44873/colbray-samuel/profile
197 - #120 Aaron Naples (Ohio) beat #19 Kyle Conel (Kent State) by DEC 6 - 4 http://www.wrestlestat.com/wrestler/51351/naples-aaron/profile
285 - #10 Amarveer Dhesi (Oregon State) beat #3 Tanner Hall (Arizona State) by DEC 9 - 5 http://www.wrestlestat.com/wrestler/14223/dhesi-amarveer/profile
285 - #9 Nathan Butler (Stanford) beat #3 Tanner Hall (Arizona State) by TB-2 3 - 2 http://www.wrestlestat.com/wrestler/14443/butler-nathan/profile