CTE is the result of repeated TBI. TBI becomes easier and easier with each iteration of it. TBI is the result of the brain moving through the cerebral fluid (the breaks) with enough speed that brain matter impacts the cranium and then swells or bleeds. The way that the brain matter achieves enough speed to overcome the cerebral fluid is through large accelerations as the cerebral fluid (a viscous fluid) acts to decelerate the brain matter.
Large accelerations are achieved by having large impulses (a large force as a function of time times (really the dot product) the differential element of time of impact). There are two ways to analyze the impulse of a collision.
1) Maximizing the force experienced due to impact which then maximizes the acceleration of the brain matter (F=ma), can be achieved when the time of the collision is reduced. This is done when you have a) a fast, violent hit and b) the collision occurs over a smaller surface area that is harder and therefore less compression and envelopment occurs on the impact surfaces (think of dropping an egg on the floor versus if it were to be dropped into a net that envelopes it and slows the collision down or in the practical sense of this discussion, a helmet to helmet hit).
2) Maximizing the acceleration can be achieved by maximizing the rate of momentum change with respect to time (F = dP/dt, or the original way Newton's 2nd law was written dP/dt = ma). To maximize the rate of change of momentum with respect to time, you would need to decrease the time of collision (we already covered this) or maximize the change in momentum (p = mv) by either increasing the masses or the velocity of the masses in the collision.
The point of the above analysis is that the larger and faster the players in the collisions as well as helmet to helmet collisions maximize the acceleration of the brain matter causing a higher likelihood of that brain matter impacting the skull (and with greater force) of the players. The force of the impact of the brain matter with the skull usually results in more trauma to the brain matter.
This is why we have helmets in the first place btw. They cause a slower head-to-head collision over a greater surface area with more deformation than if it were skull to skull. The unfortunate thing is that additional protection can be viewed as a weapon. I have some concepts for improved helmet design based on physics (a mix of similar concepts used in auto safety design and hydraulic breaks). But the crux of the problem is always going to be bigger players, moving faster, and hitting helmet to helmet.