Thread on testing & treatment research for COVID-19
- Thread starter dailybuck777
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Two minutes using Google, and you could fully understand the situation. Instead, you want to spin all kinds of hypotheticals and conspiracy theories.
The Operation Warp Speed agreement with Pfizer was for $1.95 billion. It was an advance-purchase agreement for 100 million doses of the vaccine. Pfizer does not get a penny from the US government until 100 million doses are delivered in the USA. It's actually a pretty simple, and rather standard, contract, and there isn't anything fungible about it.
I didn't say anything about hypotheticals or conspiracy theories. Pfizer said they would deliver 20 million doses and now they're cutting that number in half. They say it's due to supply chain issues but didn't offer specifics. I said we need a better explanation. What's hypothetical and where's the conspiracy?
I also said that money is fungible and the $1.95 billion would pay for a lot of different things. I think it's safe to say that some will cover development, some will cover production costs, and some will be profit. I think there's no doubt they were motivated by big orders from the U.S. as well as other countries.
I did say that I thought the U.S. was guaranteeing payment even if not FDA approved and I stand corrected. But I never suggested any type of conspiracy.
No idea where you are getting this "20 million dose number." Pfizer cut an earlier production estimate of 100 million doses in 2020 to 50 million, the latter enough to vaccinate 25 million people.
There was an earlier report that Pfizer had already produced 20 million doses.
who said there were not solutions. My point is 100 million people being given a double dose of vaccine in the next 12 weeks isn't going to happen. i'll take your wager on that. if you are in the business, than you must be in sales if you are saying you think that there will be 100 million doses available in the next 8 weeks, as Pfizer already cut there number in half and I am willing to bet you more money that 50% number will get delayed delivery as well. i am sure these guys are going balls to the wall to do as much as they can, but only so much can be done.
I just googled to test my memory. A Reuters article and a Washington Post article both mentioned 20 million doses this year (and 20 million per month after that). A November 17th Boston Globe article quotes Fauci as saying we could have 25 million from Pfizer and 15 million from Moderna. I'm not saying I'm right, I'm just saying what I've read in several places.
Perhaps your numbers are worldwide and my numbers are U.S.
P.S. I just heard Dr Hahn on TV say that he still thinks we could get 20 million doses from Pfizer by year end.
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I don't know what can realistically be done but I would expect their public announcements to be based on their best collective thinking.
Huh? Pfizer says 50 mil, which translates into 25mm people. I've seen nothing where Pfizer talks about delivering 10 mm doses.
below cut and past from article from today after yesterday's announcement that they would not meet the 100 million doses previously stated a couple of months ago. notice the hedge.....UP TO.....before the 50 million doses. these companies are not stupid. I am 100% certain Pfizer is doing everything possible to maximize the doses they can produce as it both is the right thing to do for the world and just happens to make them the most money. But again, by end of year I would be in the 25-30 million doses range which is 12-15 million people. Then they all have to get distributed and people vaccinated.
Pfizer is planning to distribute up to 50 million doses of its shot, dubbed BNT162b2, by the end of the year, a significant cut from the 100 million doses the drugmaker initially intended. Back in November, those plans were revised due to a slower-than-expected manufacturing scale-up and raw material shortages, a Pfizer spokesman said.
I kindly suggested this to him a while back but he does not seem to understand what will take place.
Fair enough, but that's a little different than saying Pfizer was cutting its plan from 20mm does to up to 10 mm. At the end of the day, it may be just 10mm (although I believe they have previously stated that they had already manufactured 20mm). Unforeseen shit happens. Like you, I think that Pfizer is doing its best.
Link to a really good Q & A with Dr. Paul Offit, a pediatrician at UPenn (CHOP), who specializes in infectious disease, and is a co-inventor of the rotavirus vaccine. He is also on the FDA committee for the SARS-Cov-2 vaccine. He and the others on the committee have the Pfizer data now, and are reviewing it ahead of the meeting 12/10. He anticipates it being cleared to ship 12/15.
--The virus only enters the blood stream in only about one percent of those infected. The vasculitis and its resultant organ damage is all due to a hyperactive immune response.
--Fever after a vaccination is a good thing. Our bodies immune system has a more optimal response with an elevated temperature. The fever is due to our immune response, not that you have the infection. Also taking antipyretics , e.g. Tylenol, to cut the temp will slightly reduce the efficacy of the vaccine. If you have a temp and can handle it, avoid taking these meds. One of the patients in the double blinded study was a doctor. He was pumped when he developed a temp as he figured he was not in the placebo group.
--If the vaccine was delivered as straight mRNA our bodies would break it down immediately and it would not be effective. The development of the lipid nanoparticles helps make the mRNA vaccine possible. Producing more lipid nanoparticles has also slowed the production of the vaccine in large amounts. Scaling the nanoparticle production up is a new challenge.
--There is probably some bias in the vaccine trial groups. People that are on average healthier than the general public tend to be those who enroll. Healthcare workers tend to participate , and this group would be more likely to follow the masking and social distancing measures, and subsequently might result in a lower efficacy rate than 95%. The end number will still be impressive.
zdoggmd.com
--The virus only enters the blood stream in only about one percent of those infected. The vasculitis and its resultant organ damage is all due to a hyperactive immune response.
--Fever after a vaccination is a good thing. Our bodies immune system has a more optimal response with an elevated temperature. The fever is due to our immune response, not that you have the infection. Also taking antipyretics , e.g. Tylenol, to cut the temp will slightly reduce the efficacy of the vaccine. If you have a temp and can handle it, avoid taking these meds. One of the patients in the double blinded study was a doctor. He was pumped when he developed a temp as he figured he was not in the placebo group.
--If the vaccine was delivered as straight mRNA our bodies would break it down immediately and it would not be effective. The development of the lipid nanoparticles helps make the mRNA vaccine possible. Producing more lipid nanoparticles has also slowed the production of the vaccine in large amounts. Scaling the nanoparticle production up is a new challenge.
--There is probably some bias in the vaccine trial groups. People that are on average healthier than the general public tend to be those who enroll. Healthcare workers tend to participate , and this group would be more likely to follow the masking and social distancing measures, and subsequently might result in a lower efficacy rate than 95%. The end number will still be impressive.
COVID Vaccine Update 12/4/20 (w/Dr. Paul Offit)
Your biggest vaccine questions, answered.
zdoggmd.com
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Was talking to my cousin who was a former high level employee at Merck. She was significantly involved in a number of vaccines during her time there. She has still has a lot of contacts in the industry and has said people are telling her that SARS CoV- 2 vaccines may have to be yearly.
I hope her experts are wrong.
I hope her experts are wrong.
In the link above, Dr Offit said it’s too early to tell how frequently the vaccine may need to be readministered . But the findings to date are supportive of a longer term immunity .
Yeah, I know with SARS and MERS immunity seems to be durable and these are very closely related viruses.
I keep reading reports about second infections. My 19 year old nephew might even have one now. He didn’t get tested the first time. It was in March and many people in his dorm developed a flu like illness. The illnesses reportedly began with two kids in the dorm who had recently traveled to the Wuhan area.
Saw the following composition posted on my local Nextdoor page this morning. It is distinctly non-political and has a hopeful ending, so I thought I would post it here:
Twas the Month Before Christmas 2020.
T’was a month before Christmas,
And all through the town,
People wore masks,
That covered their frowns.
The frown had begun
Way back in the Spring,
When a global pandemic
Changed everything.
They called it Corona,
But unlike the beer,
It didn’t bring good times,
It didn’t bring cheer.
Contagious and deadly,
This virus spread fast,
Like a wildfire that starts
When fueled by gas.
Airplanes were grounded,
Travel was banned.
Borders were closed
Across air, sea and land.
As the world entered lockdown
To flatten the curve,
The economy halted,
And folks lost their verve.
From March to July
We rode the first wave,
People stayed home,
They tried to behave.
When summer emerged,
The lockdown was lifted.
But away from caution,
Many folks drifted.
Now it’s November
And cases are spiking,
Wave two has arrived,
Much to our disliking.
Frontline workers,
Doctors and nurses,
Try to save people,
From riding in hearses.
This virus is awful,
This COVID-19.
There isn’t a cure.
There is no vaccine.
It’s true that this year
Has had sadness a plenty,
We’ll never forget
The year 2020.
And just ‘round the corner -
The holiday season,
But why be merry?
Is there even one reason?
To decorate the house
And put up the tree,
When no one will see it,
No-one but me.
But outside my window
The snow gently falls,
And I think to myself,
Let’s deck the halls!
So, I gather the ribbon,
The garland and bows,
As I play those old carols,
My happiness grows.
Christmas ain’t cancelled
And neither is hope.
If we lean on each other,
I know we can cope.
November 2020 - Author ?
Twas the Month Before Christmas 2020.
T’was a month before Christmas,
And all through the town,
People wore masks,
That covered their frowns.
The frown had begun
Way back in the Spring,
When a global pandemic
Changed everything.
They called it Corona,
But unlike the beer,
It didn’t bring good times,
It didn’t bring cheer.
Contagious and deadly,
This virus spread fast,
Like a wildfire that starts
When fueled by gas.
Airplanes were grounded,
Travel was banned.
Borders were closed
Across air, sea and land.
As the world entered lockdown
To flatten the curve,
The economy halted,
And folks lost their verve.
From March to July
We rode the first wave,
People stayed home,
They tried to behave.
When summer emerged,
The lockdown was lifted.
But away from caution,
Many folks drifted.
Now it’s November
And cases are spiking,
Wave two has arrived,
Much to our disliking.
Frontline workers,
Doctors and nurses,
Try to save people,
From riding in hearses.
This virus is awful,
This COVID-19.
There isn’t a cure.
There is no vaccine.
It’s true that this year
Has had sadness a plenty,
We’ll never forget
The year 2020.
And just ‘round the corner -
The holiday season,
But why be merry?
Is there even one reason?
To decorate the house
And put up the tree,
When no one will see it,
No-one but me.
But outside my window
The snow gently falls,
And I think to myself,
Let’s deck the halls!
So, I gather the ribbon,
The garland and bows,
As I play those old carols,
My happiness grows.
Christmas ain’t cancelled
And neither is hope.
If we lean on each other,
I know we can cope.
November 2020 - Author ?
so as i keep beating a dead horse, i really think this roll out is going to be very bad. seems like nobody knows what the F is going on. when hospital CEO's are coming out and saying they don't know anything other than they are given a new date every few days on when the vaccine is coming, including not knowing how many they will get, something is wrong. sounds like they really don't have much of a plan on how to even vaccinate people considering they don't know the side effects and good point in not being able to vaccinate the whole hospital in a day and then have 33% of the staff call out sick for a few days as they have mild to intermediate symptions.
Don't get me wrong, vaccine is what we need, but notice how the timeline is going from 'December' to hopefully we will be vaccinating nursing homes by February.
Ivermectin effective in treating mild Covid-19
Covid-19 patients that received a five-day course of the anti-parasitic drug ivermectin have shown an early viral clearance and improvements of blood biomarkers compared with other two control groups, researchers found in their study at icddr,b.
Pfizer tells U.S. officials it cannot supply substantial additional vaccine until late June or July — The Washington Post
Trump administration officials deny there will be availability issues, but others say problems are possible in the second quarter.
Just wondering if this means that people with antibodies to SARS CoV - 2 have to go to the back of the line ?
Pfizer tells U.S. officials it cannot supply substantial additional vaccine until late June or July — The Washington Post
Trump administration officials deny there will be availability issues, but others say problems are possible in the second quarter.apple.news
Delphi Research showing 99% to 95% mask compliance in every major (by population) county in America
