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Thread on testing & treatment research for COVID-19

Good luck with that. No one should be required to get this vaccine (and I plan to get it just to make non-medical life easier).
If others want to risk their life and not get the vaccine that is on them. I am going to get the shot as soon as it is available.
 
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Just received my 2nd dose of the Pfizer vaccine. Slight soreness at the injection site with the first dose but no other side effects. We'll see what happens with this one.
To quote my infectious disease specialist friend, "Most younger people do fine with covid, until they don't." He has seen many die who were below the age of 50; many, many more "younger" people that this virus absolutely knocked the $hit out of before they recovered.
I hope everyone stays safe and healthy.
 
I was fortunate enough to receive the Moderna vaccine yesterday. Aside from some mild arm soreness, I had no reaction. Some of the staff with whom I worked are refusing to get it. I hope they change their minds before they become exposed. I do not understand their reasoning, if it is reasoning.
I really hope we can ramp this up before the spring. These new variants are very worrying.
 
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New study on CV19 asymptomatic/presymptomatic/symptomatic spread

https://jamanetwork.com/journals/ja...ferral&utm_campaign=ftm_links&utm_term=010721

"Results The baseline assumptions for the model were that peak infectiousness occurred at the median of symptom onset and that 30% of individuals with infection never develop symptoms and are 75% as infectious as those who do develop symptoms. Combined, these baseline assumptions imply that persons with infection who never develop symptoms may account for approximately 24% of all transmission. In this base case, 59% of all transmission came from asymptomatic transmission, comprising 35% from presymptomatic individuals and 24% from individuals who never develop symptoms. Under a broad range of values for each of these assumptions, at least 50% of new SARS-CoV-2 infections was estimated to have originated from exposure to individuals with infection but without symptoms. "
 
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Biden announced today he will have all doses of the vaccines shipped immediately so that more people get a single dose, which the manufacturers say is about 50% effective. It will probably delay people getting their second shot and no one know this will affect effectiveness. With two doses the vaccines are 94.5% effective.
 
Biden announced today he will have all doses of the vaccines shipped immediately so that more people get a single dose, which the manufacturers say is about 50% effective. It will probably delay people getting their second shot and no one know this will affect effectiveness. With two doses the vaccines are 94.5% effective.

didn't the FDA literally just say UK was wrong for doing this?
 
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Biden announced today he will have all doses of the vaccines shipped immediately so that more people get a single dose, which the manufacturers say is about 50% effective. It will probably delay people getting their second shot and no one know this will affect effectiveness. With two doses the vaccines are 94.5% effective.
didn't the FDA literally just say UK was wrong for doing this?

Not exactly the same thing. From the below article:
1. While the transition’s announcement Friday makes sense, it also may be mostly symbolic, as it’s not clear that the practice of keeping doses in reserve was going to be permanent. Last week, Nancy Messonnier, an expert at the Centers for Disease Control and Prevention, indicated during a STAT virtual event that the policy was a moving target.
2. Over time, holding the doses in reserve made less and less sense. A recent analysis published by researchers in Ottawa argued that even holding half the doses in reserve would mean more people would get Covid. Holding them all in reserve only makes sense if a massive shortfall in manufacturing is expected.

 
Not peer reviewed, but encouraging results regarding the efficacy of the Pfizer vaccine against the UK and S. African variants.

 
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Not exactly the same thing. From the below article:
1. While the transition’s announcement Friday makes sense, it also may be mostly symbolic, as it’s not clear that the practice of keeping doses in reserve was going to be permanent. Last week, Nancy Messonnier, an expert at the Centers for Disease Control and Prevention, indicated during a STAT virtual event that the policy was a moving target.
2. Over time, holding the doses in reserve made less and less sense. A recent analysis published by researchers in Ottawa argued that even holding half the doses in reserve would mean more people would get Covid. Holding them all in reserve only makes sense if a massive shortfall in manufacturing is expected.

Doesn’t make sense to ship all as there is no research to verify that policy. What happened to ‘follow the science’? And there have been 20,000,000 shipped so far and less than 5,000,000 have been administered. NY has even had to discard unused vaccines.

Update: 29,600,000 have Ben shipped, only 6,700,000 administered.
 
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Not peer reviewed, but encouraging results regarding the efficacy of the Pfizer vaccine against the UK and S. African variants.

There is a virologist by the name of Crotty who has a number of videos on YouTube with a recent one on this very subject. He appears to really know this subject and he believed it would probably take years of additional mutations before the vaccines would be ineffective.
The good news is with the mRNA platforms, vaccines could be changed much more quickly. There could maybe even be multivalent versions. I don’t know how the approval process might look for something like this.
This, however, underscores that this is a global problem. Ultimately, for this virus to be brought under serious control anywhere, it has to be addressed everywhere. If there are new mutants popping up all over the globe, air travel is going to quickly disperse them just as we have already seen. A lot of resources and effort are going to have to be devoted if we ever hope to end this scourge.
 
Not exactly the same thing. From the below article:
1. While the transition’s announcement Friday makes sense, it also may be mostly symbolic, as it’s not clear that the practice of keeping doses in reserve was going to be permanent. Last week, Nancy Messonnier, an expert at the Centers for Disease Control and Prevention, indicated during a STAT virtual event that the policy was a moving target.
2. Over time, holding the doses in reserve made less and less sense. A recent analysis published by researchers in Ottawa argued that even holding half the doses in reserve would mean more people would get Covid. Holding them all in reserve only makes sense if a massive shortfall in manufacturing is expected.


so basically give out all the doses and assume that you will get a continued supply such that you will be able to give the second dose. So more like just in time manufacturing or logistics. that makes sense considering the horrible way this has been rolled out. Makes things a lot easier in the sense that basically you get the vaccine and then you vaccinate as many people as possible as fast as possible. Schedule them for the second visit and if there is vaccine available then they get it, if not they have to wait. But that means the vaccine dosages get into as many arms as possible as quickly as possible. i can go along with that.

and the point at end of article on politicians within states arguing who gets what is exactly why the CDC (federal govt) should have put out the list of people in order who should get the vaccine that was to be followed nationally. then there would be no politicians or local health administrators trying to figure it out themselves.
 
It doesn't make any sense at all to make more vaccines available when states can't even figure out how to distribute the ones they have.
Yep, that is the issue. Why send more when they can’t get the current supply injected? The problem is at the retail, injection sites. State and local officials need to step up and fix the problems.

DeBlasio is screaming at Cuomo to allow the city to start injecting people over 75 as the first tier hospital and first responders are refusing to take it so he has 250,000 in NYC alone unused.

Mass shipping of the entire stockpile will only end up with a large amount being discarded.
 
so basically give out all the doses and assume that you will get a continued supply such that you will be able to give the second dose. So more like just in time manufacturing or logistics. that makes sense considering the horrible way this has been rolled out. Makes things a lot easier in the sense that basically you get the vaccine and then you vaccinate as many people as possible as fast as possible. Schedule them for the second visit and if there is vaccine available then they get it, if not they have to wait. But that means the vaccine dosages get into as many arms as possible as quickly as possible. i can go along with that.

and the point at end of article on politicians within states arguing who gets what is exactly why the CDC (federal govt) should have put out the list of people in order who should get the vaccine that was to be followed nationally. then there would be no politicians or local health administrators trying to figure it out themselves.
A, the science doesn’t say that wil work since they were tested only with strict, specific intervals. And B, they have only used a quarter of what was shipped. Sending four times as much will resulting massive amounts being ruined and discard3d.
 
Yep, that is the issue. Why send more when they can’t get the current supply injected? The problem is at the retail, injection sites. State and local officials need to step up and fix the problems.

DeBlasio is screaming at Cuomo to allow the city to start injecting people over 75 as the first tier hospital and first responders are refusing to take it so he has 250,000 in NYC alone unused.

Mass shipping of the entire stockpile will only end up with a large amount being discarded.
I wanna barf. How many needless deaths and hospitalizations will this incompetence cause ?
 
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