Thread on testing & treatment research for COVID-19

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Cletus11]

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So is this basically saying that if you only get one dose of the two dose vaccine that the potential for a mutant virus that can render the current vaccines inoperable increases? So basically akin to bacteria resistant to antibiotics in a way. I think that does make sense as people are mainly resistant but not fully so the potential for a mutant virus to be able to figure out a way around partial resistance has a much better chance.

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Agoodnap]

So is this basically saying that if you only get one dose of the two dose vaccine that the potential for a mutant virus that can render the current vaccines inoperable increases? So basically akin to bacteria resistant to antibiotics in a way. I think that does make sense as people are mainly resistant but not fully so the potential for a mutant virus to be able to figure out a way around partial resistance has a much better chance.

Here, you decide...from the article.

Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. We then explore three scenarios of selection and find that a one-dose policy may increase the potential for antigenic evolution under certain conditions of partial population immunity. We highlight the critical need to test viral loads and quantify immune responses after one vaccine dose, and to ramp up vaccination efforts throughout the world.

 

[Cletus11]

Here, you decide...from the article.

Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. We then explore three scenarios of selection and find that a one-dose policy may increase the potential for antigenic evolution under certain conditions of partial population immunity. We highlight the critical need to test viral loads and quantify immune responses after one vaccine dose, and to ramp up vaccination efforts throughout the world.

so just a hypothesis basically. Although i think the hypothesis is sound.

 

[interrobang]

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"Recruited" in Cuba. I'm sure they were all willing volunteers.

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[The Spin Meister]

Here, you decide...from the article.

Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. We then explore three scenarios of selection and find that a one-dose policy may increase the potential for antigenic evolution under certain conditions of partial population immunity. We highlight the critical need to test viral loads and quantify immune responses after one vaccine dose, and to ramp up vaccination efforts throughout the world.

More maybe .....possibly ......might ......science. Of course things are possible. How about a discussion of how likely or unlikely?

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

A study on the J&J vaccine

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[Tom McAndrew]

 

[The Spin Meister]

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Lots of schools have been open all year and are safe. Especially private schools. Schools in Europe have been open.

 

[interrobang]

Lots of schools have been open all year and are safe. Especially private schools. Schools in Europe have been open.

Yep, thousands of examples out there that schools can (and have been) safely open since last summer.

 

[SLUPSU]

SIAP - results look excellent but they may be too late to the party

 

[Cletus11]

SIAP - results look excellent but they may be too late to the party

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Gonna need Novavax one shot vaccine for rest of world. So the USA approving them (which basically signals to the rest of the world they can use it) is a big thing. So for the USA, yeah Novavax won't really be in play. But for South America, Africa, and Asia it will be a big player along with J&J.

 

[roswelllion]

Here, you decide...from the article.

Building on an existing immuno-epidemiological model, we find that in the short-term, focusing on one dose generally decreases infections, but longer-term outcomes depend on this relative immune robustness. We then explore three scenarios of selection and find that a one-dose policy may increase the potential for antigenic evolution under certain conditions of partial population immunity. We highlight the critical need to test viral loads and quantify immune responses after one vaccine dose, and to ramp up vaccination efforts throughout the world.

I love it. "in our MODEL something MAY happen under CERTAIN conditions.

 

[interrobang]

SIAP - results look excellent but they may be too late to the party

For the USA at least. Still a lot of unfilled demand for vaccines in other parts of the world.

 

[Tom McAndrew]

 

[Tom McAndrew]