Thread on testing & treatment research for COVID-19
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IIRC, not ALL are requiring freezing and two doses. I don't recall the specifics per manufacturer. But some countries have taken these two concerns into consideration when producing their respective vaccines.
There is ongoing research on nanovaccines that could hopefully bypass the need for refrigeration .
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A lot of political bias in that article
Four vaccines are in Phase 3. The Moderna and Pfizer/BioNTech vaccines are mRNA based requiring subzero storage conditions. The Astra Zeneca and Johnson & Johnson vaccines are adenovirus vectors to present the spike protein of SARS-CoV-2 and both are stored refrigerated but not frozen. The Astra Zeneca vaccine will use 2 doses a month apart in the Phase 3 trial while the J&J vaccine is a single dose.
Please illustrate with some examples of statements from the article that are false.
J&J had to pause their trial so they are behind now. I think that Moderna and Pfizer are the farthest along.
Without rereading...
Claims that China was open and allowed the WHO in. Doesn't mention that they refused to allow CDC scientists in.
Suggested that Trump lied about severity. Everybody including Fauci, Redmond, etc. underestimated the risk. Task force held it's first press conference in January, spoke openly, and took questions. What scientists knew was hardly hidden.
Trump has said as recently as 2 weeks ago that the virus is no worse than the flu. The difference between a respectable scientist like Fauci and a Trump is that Fauci changes his mind when he is wrong. Doubling down on an error when you know it is wrong makes it a lie.
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Moderna and Pfizer/BioNTech both started around July 27 while Astra Zeneca began phase 3 on Sept 1 and J&J around Sept 23. Both Astra Zeneca and J&J trials are on pause in US (Astra Zeneca has resumed in U.K. trials). Pfizer seems to be the closest and then Moderna by a few weeks. Astra Zeneca and J&J probably around 1 - 2 months later even before the trials were paused. Obviously it depends how long the are paused but the best case is for sometime in Q1 of 2021.
Well he did have it so is reporting his experience is a lie? Others have different experiences based on their underlying health issues. Try dropping the political BS for once.
Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition
Yu et al demonstrate that SARS-CoV-2 spike protein subunits activate the alternative pathway of complement in vitro, suggesting that many clinical manifestation
ashpublications.org
He's not just explaining his experience. He is telling his supporters that a pandemic that has killed more Americans than both sides in combat in the Civil War is just a little flu. So how about YOU drop the political BS and start dealing in facts.
Now if only the FDA would stop holding these vaccine trials hostage like they are with AstraZeneca and now Johnson and Johnson.
Seriously? FDA has been the literal gold standard for the entire world for decades on drugs. You don't screw around with a vaccine that will eventually be given to billions of people. No compromise allowed there.
No, that is not what he is saying. You need to listen to him speak and not listen to how CNN and MSNBC paraphrase him. He is saying be smart, use all possible precautions, but don't let this define you. Live your life.
Both were paused by the companies themselves. J & J was just paused one week ago so entirely premature to know what the impact is yet. FDA isn’t holding either hostage. This vaccines in Phase III now have reached that point faster than any previous vaccine.
FDA is holding AstraZeneca hostage. The trials have continued in the UK and Japan, but the FDA won't let them restart in the USA. It's likely they do the same with J&J
www.statnews.com
As AstraZeneca’s Covid-19 vaccine trial remains on hold in U.S., participants waiting on a second dose are in limbo
For participants who received an initial shot — but haven't yet received a second dose — the continued hold on AstraZeneca's Covid-19 vaccine trial in the U.S. has become a waiting game.
www.statnews.com
FDA is holding AstraZeneca hostage. The trials have continued in the UK and Japan, but the FDA won't let them restart in the USA. It's likely they do the same with J&J
As AstraZeneca’s Covid-19 vaccine trial remains on hold in U.S., participants waiting on a second dose are in limbo
For participants who received an initial shot — but haven't yet received a second dose — the continued hold on AstraZeneca's Covid-19 vaccine trial in the U.S. has become a waiting game.
The UK is satisfied to move forward while the FDA wants to see more info about adverse events from other clinical trials using the same adenovirus platform that Astra Zeneca used. Given that the U.K. appears to move forward with human challenge trials it is perhaps not surprising that they have a different risk perspective that the US.
Dozens to be deliberately infected with coronavirus in UK ‘human challenge’ trials
Proponents of the trials say they can be run safely and help to identify effective vaccines, but others have questioned their value.
www.nature.com
Studies Point To Big Drop In COVID-19 Death Rates
More hospitalized patients are surviving than early in the pandemic. Improved treatments make a big difference, but so does flattening the curve to keep hospitals from overfilling, researchers say.
www.npr.org
That is not all he has said. He tweets and repeatedly says at his rallies that this is no worse than the flu. Not paraphrasing. Not at all. Check out the fact checkers. Or maybe you don't believe them either.
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The mouthwash and oral rinses were also efficacious, they found: "Many inactivated greater than 99.9% of virus after only 30 seconds of contact time and some inactivated 99.99% of the virus after 30 seconds.”
https://www.foxnews.com/health/human-coronaviruses-inactivated-mouthwash-oral-rinses-study
https://www.foxnews.com/health/human-coronaviruses-inactivated-mouthwash-oral-rinses-study
